General Information

  • ID:  hor005670
  • Uniprot ID:  P57774
  • Protein name:  C-flanking peptide of NPY
  • Gene name:  Npy
  • Organism:  Mus musculus (Mouse)
  • Family:  NPY family
  • Source:  Animal
  • Expression:  One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Mus (subgenus), Mus (genus), Murinae (subfamily), Muridae (family), Muroidea, Myomorpha (suborder), Rodentia (order), Glires, Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0001664 G protein-coupled receptor binding; GO:0005179 hormone activity; GO:0005184 neuropeptide hormone activity; GO:0031841 neuropeptide Y receptor binding
  • GO BP:  GO:0001878 response to yeast; GO:0002865 negative regulation of acute inflammatory response to antigenic stimulus; GO:0007218 neuropeptide signaling pathway; GO:0007268 chemical synaptic transmission; GO:0007631 feeding behavior; GO:0008217 regulation of blood pressure; GO:0008284 positive regulation of cell population proliferation; GO:0008343 adult feeding behavior; GO:0010811 positive regulation of cell-substrate adhesion; GO:0019731 antibacterial humoral response; GO:0019732 antifungal humoral response; GO:0021954 central nervous system neuron development; GO:0021987 cerebral cortex development; GO:0031175 neuron projection development; GO:0032100 positive regulation of appetite; GO:0032903 regulation of nerve growth factor production; GO:0042117 monocyte activation; GO:0045087 innate immune response; GO:0045776 negative regulation of blood pressure; GO:0045964 positive regulation of dopamine metabolic process; GO:0050829 defense response to Gram-negative bacterium; GO:0050830 defense response to Gram-positive bacterium; GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide; GO:0070374 positive regulation of ERK1 and ERK2 cascade; GO:0099509 regulation of presynaptic cytosolic calcium ion concentration; GO:0099538 synaptic signaling via neuropeptide; GO:1904000 positive regulation of eating behavior; GO:1904407 positive regulation of nitric oxide metabolic process; GO:2000300 regulation of synaptic vesicle exocytosis
  • GO CC:  GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005737 cytoplasm; GO:0005794 Golgi apparatus; GO:0031410 cytoplasmic vesicle; GO:0043195 terminal bouton; GO:0043204 perikaryon; GO:0048471 perinuclear region of cytoplasm; GO:0098982 GABA-ergic synapse; GO:0098992 neuronal dense core vesicle

Sequence Information

  • Sequence:  SSPETLISDLLMKESTENAPRTRLEDPSMW
  • Length:  30(68-97)
  • Propeptide:  MLGNKRMGLCGLTLALSLLVCLGILAEGYPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRYGKRSSPETLISDLLMKESTENAPRTRLEDPSMW
  • Signal peptide:  MLGNKRMGLCGLTLALSLLVCLGILAEG
  • Modification:  T16 Phosphothreonine
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  Npy1r
  • Target Unid:  Q04573
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P57774-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor005670_AF2.pdbhor005670_ESM.pdb

Physical Information

Mass: 395226 Formula: C146H237N39O52S2
Absent amino acids: CFGHQVY Common amino acids: S
pI: 4.1 Basic residues: 3
Polar residues: 9 Hydrophobic residues: 7
Hydrophobicity: -79.67 Boman Index: -7798
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 68.33
Instability Index: 6611.33 Extinction Coefficient cystines: 5500
Absorbance 280nm: 189.66

Literature

  • PubMed ID:  NA
  • Title:  NA